Search results for "Intercalated Cell"

showing 3 items of 3 documents

Intercalated cells as a probable source for the development of renal oncocytoma

1988

Renal oncocytoma is a distinct type of epithelial tumor said to arise from the collecting duct system. Here we show that in nine of ten oncocytomas the tumor cells expressed an analog of the erythrocyte anion exchanger band 3. In the normal kidney band 3 is confined to the basolateral surface of the majority of intercalated cells which comprise up to 50% of the cortical collecting duct epithelium. Carbonic anhydrase c is another protein abundant in intercalated cells, and this was also expressed in six of the ten oncocytomas investigated. Immunoreactivity specific for band 3 and carbonic anhydrase c was not detected in any of the 20 renal cell carcinomas examined. At favourable section plan…

AdenomaKidneyPathologymedicine.medical_specialtyStaining and LabelingbiologyChemistryurologic and male genital diseasesmedicine.diseaseImmunohistochemistryKidney NeoplasmsCholangiocytemedicine.anatomical_structureCarbonic anhydrasemedicinebiology.proteinHumansCollecting duct systemIntercalated CellOncocytomaKidney Tubules CollectingRenal oncocytomaBand 3Anion Exchange ResinsVirchows Archiv B Cell Pathology Including Molecular Pathology
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Klassifikation der Nierenzellkarzinome/Tumoren und ihre Beziehung zum Nephron-Sammelrohrsystem

1990

After a controversial phase of nomenclature (including--among others--the terms "hypernephroma" and "hypernephroid carcinoma") a cytomorphologically defined subtyping of renal cell tumours (adenomas, carcinomas, oncocytomas) is offered, based on new electron microscopical and histochemical observations. These data are in part supported by cytogenetical findings reported in the literature. Phenotypical/histogenetical relations to different parts or cell types, respectively, of the nephron-collecting duct system could be demonstrated. Chromophobe cell carcinoma and oncocytoma exhibit features of the intercalated cells.

Cell typePathologymedicine.medical_specialtyGeneral MedicineChromophobe cellBiologyurologic and male genital diseasesmedicine.diseaseDrug DiscoveryCarcinomamedicineMolecular MedicineIntercalated CellOncocytomaGenetics (clinical)Klinische Wochenschrift
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The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct.

1988

In the present study we have examined ten cases of the chromophobe type renal cell carcinoma. This type of tumor is distinguished from the other carcinomas of the kidney with light cytoplasm (formerly called “hypernephroid”) by (a) a positive Hale’s iron colloid stain of the cytoplasm, (b) the occurrence of numerous invaginated vesicles within the cytoplasm that resemble the invaginated vesicles of intercalated cells of the collecting duct system, and (c) a positive immunoreaction of both the plasma membrane and the cytoplasm with antibodies to the epithelial membrane antigen (EMA) and carbonic anhydrase C (CAC), respectively. Unlike oncocytomas, which also express CAC and EMA, the chromoph…

Pathologymedicine.medical_specialtyChromophobe Renal Cell CarcinomaChromophobe cellurologic and male genital diseasesRenal cell carcinomamedicineFreeze FracturingHumansIntercalated CellKidney Tubules CollectingBand 3Anion Exchange ResinsCarbonic AnhydrasesKidneybiologymedicine.diseaseImmunohistochemistryKidney NeoplasmsMicroscopy Electronmedicine.anatomical_structureKidney TubulesCytoplasmAntigens Surfacebiology.proteinCollecting duct systemVirchows Archiv. B, Cell pathology including molecular pathology
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